Skin is the largest organ in the human body and serves several important functions. As well as having a sensory role, it provides a physical barrier against environmental factors. The two main layers that make up the skin are the epidermis and the dermis. The layers consist of cells, which are proliferating (basal), differentiated(keratinocytes), or squamous. The dermis, on the other hand, contains fibroblasts, which produce elastin and collagen both type l, type III, and other extracellular matrix proteins. This is Embedded within the collagen fiber network.(1)
The extracellular matrix accounts for almost 80% of the skin’s dry weight. For the skin to function normally and appear youthful, the structure of the dermal layer must be maintained because the dermis provides structural support to the epidermis, which carries the blood vessels and supplies the skin with important nutrients for its functioning, natural aging can affect the structural integrity of the dermis. When the body is exposed to the sun are prone to photo-aging, high sugar levels lead to the development of advanced glycation end products, these factors affect fibroblasts in the dermis by causing changes in their shape and in the amount and quality of elastin and type collagen fiber, aged fibroblasts synthesize less collagen. This results in visible signs of aging, and dry skin (“).
Why Life On Skin-Life?
Life On Skin-Life has a unique formula that contains hydrolyzed collagen, vitamins like C, D3, and minerals like manganese, and copper. Collagen is the main structural protein of the different connective tissues present in animals. It is mostly found in fibrous tissues, such as tendons and ligaments. It is a major insoluble fibrous protein found in the extracellular matrix of the skin, together with elastin and hyaluronic acid.
Collagen is mainly produced by fibroblasts in the connective tissues. Young skin is made by 80% type l collagen and about 15% collagen type IlI. Hydrolyzed collagen has low molecular weight, so it’s easily digestible, absorbed and distributed in the human body. When administered orally, hydrolyzed collagen reaches the small intestine where it is absorbed into the blood stream, both in the form of small collagen peptides and free amino acids.
Hydrolyzed collagen has a dual mechanism of action:
1. It’s free amino acids provide building blocks for the formation of collagen and elastin fibers.
2.Collagen oligopeptides act as ligands, binding to receptors present on the fibroblasts membrane and stimulate the production of new collagen, elastin and hyaluronic acid(2).
3.Vitamin C is one of the naturally occurring potent antioxidant which is used topically in dermatology to treat and prevent changes associated with photoageing and hyperpigmentation. It protects the skin from oxidative stress by sequentially donating electrons to neutralize the free radicals (3)